PRE-IMPLANTATION GENETICAL DIAGNOSIS, PGD

It is a pre pregnancy diagnosis procedure for couples who benefit from test tube baby treatments such as in vitro fertilization and microinjection-embryo transfer of pre implantation genetic diagnosis. The essence of the procedure is based on genetic analysis of one or more cellules of the embryos obtained by micromanipulation after the test tube baby treatment. The embryos that are determined as normal genetically and shapely are later transferred to the mothers uterus. With pre-implantation genetic diagnosis it is possible to determine any genetic defect before pregnancy. By this way no surgical procedures will be implemented in order to determine genetic behavior during pregnancy, end unhealthy pregnancy and surgical attempts. It is an important method that came into prominence by means of ethics, moral and patients comfort.

The method is realized by genetic examination of the PCR and FISH methods using 1 or 2 cellules from the 8 cellule embryos after the 3rd day of insemination. The name of this procedure is called embryo biopsy or blastomer biopsy. Because it takes about 1 day to take the results of the test, if the results are normal, the embryo transfer procedure is executed on the 4th or 5th day of insemination.

Pre-Implantation genetic diagnosis (PGT) should be implemented for every couple that carries the risk of a genetically transmitted disorder. Besides, it is also used to prevent chromosome anomalities that can frequently be encountered for women who are over 35 years old and applied for test tube baby treatment due to infertility. Apart from preventing baby birth with abnormal chromosome structure due to advanced age it also increases the rate of test tube baby pregnancy and live birth. Scanning the embryos with PGT to patients who are over 35 years old and transferring only the genetically fit embryos, this will not only protect the patient who endured many pregnancy procedures from surgical interventions during pregnancy but will also effect the pregnancy rates in a positive way for the genetically fit embryos.